{"id":3608,"date":"2024-01-25T17:05:28","date_gmt":"2024-01-25T16:05:28","guid":{"rendered":"https:\/\/web-frankfurt.de\/Sani\/?p=3608"},"modified":"2025-07-25T18:12:23","modified_gmt":"2025-07-25T16:12:23","slug":"chronic-administration-of-lisdexamfetamine-induces-apoptosis-and-inflammation-and-reduces-sperm-quality-in-adult-male-rats","status":"publish","type":"post","link":"https:\/\/web-frankfurt.de\/Sani\/scientific-articles\/chronic-administration-of-lisdexamfetamine-induces-apoptosis-and-inflammation-and-reduces-sperm-quality-in-adult-male-rats\/","title":{"rendered":"Chronic Administration of Lisdexamfetamine Induces Apoptosis and Inflammation and Reduces Sperm Quality in Adult Male Rats"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3608\" class=\"elementor elementor-3608\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-206d55ad e-flex e-con-boxed e-con e-parent\" data-id=\"206d55ad\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b539a12 elementor-widget elementor-widget-text-editor\" data-id=\"4b539a12\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<blockquote class=\"wp-block-quote\"><p><strong>Abstract and Figures<\/strong><\/p><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><div class=\"research-detail-header-section__metadata-after-square-logo\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">\u00a0<\/div><\/div><\/div><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\"><div class=\"nova-legacy-c-card nova-legacy-c-card--spacing-m nova-legacy-c-card--elevation-1-above\"><div class=\"nova-legacy-c-card__body nova-legacy-c-card__body--spacing-inherit\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\"><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\"><div class=\"nova-legacy-c-card nova-legacy-c-card--spacing-m nova-legacy-c-card--elevation-1-above\"><div class=\"nova-legacy-c-card__body nova-legacy-c-card__body--spacing-inherit\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\"><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\"><div class=\"nova-legacy-c-card nova-legacy-c-card--spacing-m nova-legacy-c-card--elevation-1-above\"><div class=\"nova-legacy-c-card__body nova-legacy-c-card__body--spacing-inherit\"><div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\">January 2024<\/li><li class=\"nova-legacy-e-list__item\"><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"https:\/\/www.researchgate.net\/journal\/Reproductive-sciences-Thousand-Oaks-Calif-1933-7205?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uIiwicHJldmlvdXNQYWdlIjoicHJvZmlsZSJ9fQ\">Reproductive sciences (Thousand Oaks, Calif.)<\/a>\u00a031(8)<\/li><\/ul><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">DOI: <a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"http:\/\/dx.doi.org\/10.1007\/s43032-023-01449-9\" target=\"_blank\" rel=\"noopener\">10.1007\/s43032-023-01449-9<\/a><\/div><\/div><div>\u00a0<\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\">Concerns have been raised about potentially irreversible brain damage and damage to the neuroendocrine system during development when treating attention-deficit\/hyperactivity disorder with lisdexamfetamine (LDX), a norepinephrine dopamine reuptake inhibitor. This study aims to elucidate the potential adverse effects of LDX on the male reproductive system due to its widespread use and potential for abuse. In this study, adult male rats were randomized into control and LDX groups. Thirty milligrams per kilogram LDX was administered orally for 3 weeks. After isolation of epididymal spermatozoa, the rats were euthanized and testicular tissues were collected for stereological and molecular analyses. The LDX group showed a decrease in sperm motility and an increase in DNA fragmentation compared to the control group. There was also a dramatic decrease in testosterone in the LDX group. Testicular expression of caspase-3 and TNF-\u03b1 was significantly increased in the LDX group. According to our findings, prolonged use of LDX leads to reduced sperm quality. It also induces apoptosis, inflammatory response, and pathological changes in the testicular tissue. What we have observed in this study is noteworthy but requires further investigation, particularly in people who use LDX over a longer period of time.<\/div><\/div><\/div><\/div><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/li><\/ul><\/div><\/li><\/ul><\/div><\/blockquote><blockquote class=\"wp-block-quote\"><p><strong>Authors<\/strong><\/p><ul><li style=\"list-style-type: none;\"><ul><li><a href=\"https:\/\/www.researchgate.net\/profile\/Mojtaba-Sani-2?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InByb2ZpbGUiLCJwYWdlIjoicHVibGljYXRpb24iLCJwcmV2aW91c1BhZ2UiOiJwcm9maWxlIn19\">Dr. Dr. Mojtaba Sani<\/a><\/li><li><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/profile\/Abbas-Aliaghaei?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InByb2ZpbGUiLCJwYWdlIjoicHVibGljYXRpb24iLCJwcmV2aW91c1BhZ2UiOiJwcm9maWxlIn19\"><span class=\"publication-header-author__font-weight-normal\">Dr. Abbas Aliaghaei<\/span><\/a><\/li><\/ul><\/li><\/ul><\/blockquote><blockquote class=\"wp-block-quote\"><p><strong>Source Citation<\/strong><\/p><p><a href=\"https:\/\/www.researchgate.net\/publication\/377459196_Chronic_Administration_of_Lisdexamfetamine_Induces_Apoptosis_and_Inflammation_and_Reduces_Sperm_Quality_in_Adult_Male_Rats\" target=\"_blank\" rel=\"nofollow noopener\"> <button style=\"padding: 10px 20px; font-size: 16px; background-color: #0c3a2e; color: white; border: none; border-radius: 6px; cursor: pointer;\"> Visit Source <\/button> <\/a><\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Abstract and Figures \u00a0 January 2024 Reproductive sciences (Thousand Oaks, Calif.)\u00a031(8) DOI: 10.1007\/s43032-023-01449-9\u00a0Concerns have been raised about potentially irreversible brain damage and damage to the neuroendocrine system during development when treating attention-deficit\/hyperactivity disorder with lisdexamfetamine (LDX), a norepinephrine dopamine reuptake inhibitor. This study aims to elucidate the potential adverse effects of LDX on the male <\/p>\n","protected":false},"author":1,"featured_media":2815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"class_list":["post-3608","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-articles"],"_links":{"self":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/comments?post=3608"}],"version-history":[{"count":4,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3608\/revisions"}],"predecessor-version":[{"id":3612,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3608\/revisions\/3612"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/media\/2815"}],"wp:attachment":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/media?parent=3608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/categories?post=3608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/tags?post=3608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}