{"id":3644,"date":"2025-04-10T17:28:56","date_gmt":"2025-04-10T15:28:56","guid":{"rendered":"https:\/\/web-frankfurt.de\/Sani\/?p=3644"},"modified":"2025-07-25T18:13:53","modified_gmt":"2025-07-25T16:13:53","slug":"the-neuroprotective-effect-of-elderberry-diet-on-the-tramadol-induced-toxicity-in-the-hippocampus-of-adult-male-rats","status":"publish","type":"post","link":"https:\/\/web-frankfurt.de\/Sani\/scientific-articles\/the-neuroprotective-effect-of-elderberry-diet-on-the-tramadol-induced-toxicity-in-the-hippocampus-of-adult-male-rats\/","title":{"rendered":"The Neuroprotective Effect of Elderberry Diet on the Tramadol-Induced Toxicity in the Hippocampus of Adult Male Rats"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3644\" class=\"elementor elementor-3644\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-206d55ad e-flex e-con-boxed e-con e-parent\" data-id=\"206d55ad\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b539a12 elementor-widget elementor-widget-text-editor\" data-id=\"4b539a12\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<blockquote class=\"wp-block-quote\"><p><strong>Abstract and Figures<\/strong><\/p><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"research-detail-header-section__metadata-after-square-logo\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"research-detail-header-section__metadata-after-square-logo\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">\u00a0<\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\">April 2025<\/li><li class=\"nova-legacy-e-list__item\"><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"https:\/\/www.researchgate.net\/journal\/Tissue-and-Cell-0040-8166\">Tissue and Cell<\/a>\u00a093:102757<\/li><\/ul><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">DOI: <a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"http:\/\/dx.doi.org\/10.1016\/j.tice.2025.102757\" target=\"_blank\" rel=\"noopener\">10.1016\/j.tice.2025.102757<\/a><\/div><\/li><\/ul><\/div><\/div><\/li><\/ul><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">\u00a0<\/div><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\"><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\"><div class=\"nova-legacy-c-card nova-legacy-c-card--spacing-m nova-legacy-c-card--elevation-1-above\"><div class=\"nova-legacy-c-card__body nova-legacy-c-card__body--spacing-inherit\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\">Pain relievers such as tramadol are among the most commonly prescribed around the world. However, Long-term tramadol use has been shown to cause neurotoxicity, neuroinflammation, and cognitive impairment, which has limited its clinical use. Elderberry (EB), a plant extract widely recognized for its medicinal properties, is used in this study to investigate the effects of a plant-based diet on tramadol&#8217;s adverse effects in the hippocampus region. The effects of EB oral diet on the devastating effects of tramadol on the hippocampus structure and function of 36 male albino rats were evaluated using behavioral, electrophysiological, and histological setups. Three groups (Control, Tramadol, and Tramadol+EB) were examined using behavioral, electrophysiological, and histological setups. The behavioral findings showed that the EB diet could improve most of the memory-related indices in Tramadol+EB compared to the Tramadol group. Regarding the fEPSP slope and population spike amplitude, these electrophysiological parameters returned to control levels in the Tramadol+EB group. Additionally, a decrease in caspase-3 expression was observed in hippocampal cells. While there was a reduction in astrogliosis in the Tramadol+EB group compared to the Tramadol group, no significant differences were noted in the morphological variations of astrocytes between the groups. In conclusion, although further studies are necessary to elucidate other aspects of EB&#8217;s effects on the brain, it may be considered a potential neuroprotective agent in acute to sub-chronic tramadol exposure.<\/div><\/div><\/div><\/div><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\">\u00a0<\/div><\/div><div id=\"figures\" class=\"js-target-figures\"><div class=\"nova-legacy-o-grid nova-legacy-o-grid--gutter-none nova-legacy-o-grid--order-normal nova-legacy-o-grid--horizontal-align-left nova-legacy-o-grid--vertical-align-top\"><div class=\"nova-legacy-o-grid__column nova-legacy-o-grid__column--width-12\/12@s-up\"><div class=\"nova-legacy-c-image-strip\"><div class=\"nova-legacy-c-image-strip__container\"><div class=\"publication-figures-image-strip-caption__container\"><div class=\"nova-legacy-o-stack nova-legacy-o-stack--gutter-m nova-legacy-o-stack--spacing-none nova-legacy-o-stack--no-gutter-outside\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/li><\/ul><\/div><\/li><\/ul><\/div><\/blockquote><blockquote class=\"wp-block-quote\"><p><strong>Authors<\/strong><\/p><ul><li style=\"list-style-type: none;\"><ul><li><a href=\"https:\/\/www.researchgate.net\/profile\/Mojtaba-Sani-2?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InByb2ZpbGUiLCJwYWdlIjoicHVibGljYXRpb24iLCJwcmV2aW91c1BhZ2UiOiJwcm9maWxlIn19\">Dr. Dr. Mojtaba Sani<\/a><\/li><li><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/profile\/Abbas-Aliaghaei?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InByb2ZpbGUiLCJwYWdlIjoicHVibGljYXRpb24iLCJwcmV2aW91c1BhZ2UiOiJwcm9maWxlIn19\"><span class=\"publication-header-author__font-weight-normal\">Dr. Abbas Aliaghaei<\/span><\/a><\/li><\/ul><\/li><\/ul><\/blockquote><blockquote class=\"wp-block-quote\"><p><strong>Source Citation<\/strong><\/p><p><a href=\"https:\/\/www.researchgate.net\/publication\/388433633_The_Neuroprotective_Effect_of_Elderberry_Diet_on_the_Tramadol-Induced_Toxicity_in_the_Hippocampus_of_Adult_Male_Rats\" target=\"_blank\" rel=\"nofollow noopener\"> <button style=\"padding: 10px 20px; font-size: 16px; background-color: #0c3a2e; color: white; border: none; border-radius: 6px; cursor: pointer;\"> Visit Source <\/button> <\/a><\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Abstract and Figures \u00a0 April 2025 Tissue and Cell\u00a093:102757 DOI: 10.1016\/j.tice.2025.102757 \u00a0Pain relievers such as tramadol are among the most commonly prescribed around the world. However, Long-term tramadol use has been shown to cause neurotoxicity, neuroinflammation, and cognitive impairment, which has limited its clinical use. Elderberry (EB), a plant extract widely recognized for its medicinal <\/p>\n","protected":false},"author":1,"featured_media":2815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"class_list":["post-3644","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-articles"],"_links":{"self":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3644","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/comments?post=3644"}],"version-history":[{"count":4,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3644\/revisions"}],"predecessor-version":[{"id":3648,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3644\/revisions\/3648"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/media\/2815"}],"wp:attachment":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/media?parent=3644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/categories?post=3644"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/tags?post=3644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}