{"id":3667,"date":"2025-06-18T17:38:03","date_gmt":"2025-06-18T15:38:03","guid":{"rendered":"https:\/\/web-frankfurt.de\/Sani\/?p=3667"},"modified":"2025-07-25T18:14:24","modified_gmt":"2025-07-25T16:14:24","slug":"exploring-the-spectrum-of-heroin-induced-changes-in-the-rat-brain","status":"publish","type":"post","link":"https:\/\/web-frankfurt.de\/Sani\/scientific-articles\/exploring-the-spectrum-of-heroin-induced-changes-in-the-rat-brain\/","title":{"rendered":"Exploring the spectrum of heroin-induced changes in the rat brain"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"3667\" class=\"elementor elementor-3667\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-206d55ad e-flex e-con-boxed e-con e-parent\" data-id=\"206d55ad\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b539a12 elementor-widget elementor-widget-text-editor\" data-id=\"4b539a12\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<blockquote class=\"wp-block-quote\"><p><strong>Abstract and Figures<\/strong><\/p><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"research-detail-header-section__metadata-after-square-logo\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"research-detail-header-section__metadata-after-square-logo\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\"><div class=\"research-detail-header-section__metadata-after-square-logo\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\"><ul class=\"nova-legacy-e-list nova-legacy-e-list--size-m nova-legacy-e-list--type-inline nova-legacy-e-list--spacing-none\"><li class=\"nova-legacy-e-list__item\">June 2025<\/li><li class=\"nova-legacy-e-list__item\"><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"https:\/\/www.researchgate.net\/journal\/3-Biotech-2190-5738?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uIiwicHJldmlvdXNQYWdlIjoicHJvZmlsZSJ9fQ\">3 Biotech<\/a>\u00a015(7)<\/li><\/ul><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">DOI: <a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"http:\/\/dx.doi.org\/10.1007\/s13205-025-04387-2\" target=\"_blank\" rel=\"noopener\">10.1007\/s13205-025-04387-2<\/a><\/div><\/div><\/li><\/ul><\/div><\/div><\/li><\/ul><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700\">\u00a0<\/div><\/div><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\"><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\"><div class=\"nova-legacy-c-card nova-legacy-c-card--spacing-m nova-legacy-c-card--elevation-1-above\"><div class=\"nova-legacy-c-card__body nova-legacy-c-card__body--spacing-inherit\"><div class=\"nova-legacy-e-text nova-legacy-e-text--size-m nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-none nova-legacy-e-text--color-grey-800 research-detail-middle-section__abstract\">The primary objective of this study was to investigate the effects of prolonged heroin exposure on adult male rats. Our findings demonstrate that this intervention induces deficits in memory, synaptic plasticity, emotional regulation, and motor function. These impairments appear to be associated with reduced levels of BDNF, increased expression of REST\/NRSF, and elevated astrocyte activity within the hippocampus. We employed a multimodal approach to assess the impact of heroin in 24 adult male rats following 2 weeks of daily injections. Behavioral assessments were conducted to evaluate memory and anxiety-like and depression-like behaviors, followed by tests of neuromuscular and locomotor function. Molecular and histological analyses were subsequently performed to characterize heroin-induced alterations in the brain. Heroin-treated rats showed impaired performance in cognitive tasks, evidenced by reduced scores in the Y-maze and shuttle box tests. Furthermore, heroin exposure negatively affected behavioral scores in the open field test, tail suspension test, and elevated plus maze. Electromyography (EMG) revealed increased latency, indicating disruptions in neuromuscular activity. Indicators of long-term potentiation (LTP), including population spike amplitude, and field EPSP slope, were significantly reduced following heroin administration. Immunohistochemical analysis revealed marked astrogliosis and alterations in BDNF and REST expression in the CA1 region of the hippocampus. Additionally, heroin disrupted the spatial organization of neurons. In conclusion, these results suggest that heroin exposure induces structural and functional neuronal changes, likely mediated by neuroinflammation and dysregulated neurotrophic signaling, which may underlie the observed cognitive impairments.<\/div><\/div><\/div><\/div><div class=\"nova-legacy-l-flex__item nova-legacy-l-flex__item--grow research-detail-middle-section__item\">\u00a0<\/div><\/div><div id=\"figures\" class=\"js-target-figures\"><div class=\"nova-legacy-o-grid nova-legacy-o-grid--gutter-none nova-legacy-o-grid--order-normal nova-legacy-o-grid--horizontal-align-left nova-legacy-o-grid--vertical-align-top\"><div class=\"nova-legacy-o-grid__column nova-legacy-o-grid__column--width-12\/12@s-up\"><div class=\"nova-legacy-c-image-strip\"><div class=\"nova-legacy-c-image-strip__container\">\u00a0<\/div><\/div><\/div><\/div><\/div><\/li><\/ul><\/div><\/li><\/ul><\/div><\/blockquote><blockquote class=\"wp-block-quote\"><p><strong>Authors<\/strong><\/p><ul><li style=\"list-style-type: none;\"><ul><li><a href=\"https:\/\/www.researchgate.net\/profile\/Mojtaba-Sani-2?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InByb2ZpbGUiLCJwYWdlIjoicHVibGljYXRpb24iLCJwcmV2aW91c1BhZ2UiOiJwcm9maWxlIn19\">Dr. Dr. Mojtaba Sani<\/a><\/li><li><a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-bare\" href=\"https:\/\/www.researchgate.net\/profile\/Abbas-Aliaghaei?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InByb2ZpbGUiLCJwYWdlIjoicHVibGljYXRpb24iLCJwcmV2aW91c1BhZ2UiOiJwcm9maWxlIn19\"><span class=\"publication-header-author__font-weight-normal\">Dr. Abbas Aliaghaei<\/span><\/a><\/li><\/ul><\/li><\/ul><\/blockquote><blockquote class=\"wp-block-quote\"><p><strong>Source Citation<\/strong><\/p><p><a href=\"https:\/\/www.researchgate.net\/publication\/392912240_Exploring_the_spectrum_of_heroin-induced_changes_in_the_rat_brain\" target=\"_blank\" rel=\"nofollow noopener\"> <button style=\"padding: 10px 20px; font-size: 16px; background-color: #0c3a2e; color: white; border: none; border-radius: 6px; cursor: pointer;\"> Visit Source <\/button> <\/a><\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f2a2d5 elementor-widget elementor-widget-gallery\" data-id=\"9f2a2d5\" data-element_type=\"widget\" data-settings=\"{&quot;columns&quot;:3,&quot;gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:15,&quot;sizes&quot;:[]},&quot;lazyload&quot;:&quot;yes&quot;,&quot;gallery_layout&quot;:&quot;grid&quot;,&quot;columns_tablet&quot;:2,&quot;columns_mobile&quot;:1,&quot;gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:10,&quot;sizes&quot;:[]},&quot;link_to&quot;:&quot;file&quot;,&quot;aspect_ratio&quot;:&quot;3:2&quot;,&quot;overlay_background&quot;:&quot;yes&quot;,&quot;content_hover_animation&quot;:&quot;fade-in&quot;}\" data-widget_type=\"gallery.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-gallery__container\">\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/Sholl-analysis-findings-a-EB-reversed-the-reduced-METH-induced-reduction-of-complexity.webp\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"9f2a2d5\" data-elementor-lightbox-title=\"Sholl-analysis-findings-a-EB-reversed-the-reduced-METH-induced-reduction-of-complexity\" data-elementor-lightbox-description=\"Sholl analysis findings. a EB reversed the reduced METH induced reduction of complexity of astrocyte processes. b The increased total astrocyte process of astrocytes reversed to control level in METH + EB group. c Astrocyte soma size that increased\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzY1NywidXJsIjoiaHR0cHM6XC9cL3dlYi1mcmFua2Z1cnQuZGVcL1NhbmlcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA3XC9TaG9sbC1hbmFseXNpcy1maW5kaW5ncy1hLUVCLXJldmVyc2VkLXRoZS1yZWR1Y2VkLU1FVEgtaW5kdWNlZC1yZWR1Y3Rpb24tb2YtY29tcGxleGl0eS53ZWJwIiwic2xpZGVzaG93IjoiOWYyYTJkNSJ9\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/Sholl-analysis-findings-a-EB-reversed-the-reduced-METH-induced-reduction-of-complexity.webp\" data-width=\"850\" data-height=\"515\" aria-label=\"Sholl analysis findings. a EB reversed the reduced METH induced reduction of complexity of astrocyte processes. b The increased total astrocyte process of astrocytes reversed to control level in METH + EB group. c Astrocyte soma size that increased\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/Specific-staining-was-used-to-show-and-analyze-astrocytes-and-astrogliosis-in-the.webp\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"9f2a2d5\" data-elementor-lightbox-title=\"Specific-staining-was-used-to-show-and-analyze-astrocytes-and-astrogliosis-in-the\" data-elementor-lightbox-description=\"Specific staining was used to show and analyze astrocytes and astrogliosis in the subjects&#039; hippocampus. a IHC specific staining for the astrocyte marker (GFAP). EB recovered the devastating effects\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzY1OCwidXJsIjoiaHR0cHM6XC9cL3dlYi1mcmFua2Z1cnQuZGVcL1NhbmlcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA3XC9TcGVjaWZpYy1zdGFpbmluZy13YXMtdXNlZC10by1zaG93LWFuZC1hbmFseXplLWFzdHJvY3l0ZXMtYW5kLWFzdHJvZ2xpb3Npcy1pbi10aGUud2VicCIsInNsaWRlc2hvdyI6IjlmMmEyZDUifQ%3D%3D\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/Specific-staining-was-used-to-show-and-analyze-astrocytes-and-astrogliosis-in-the.webp\" data-width=\"850\" data-height=\"570\" aria-label=\"Specific staining was used to show and analyze astrocytes and astrogliosis in the subjects&#039; hippocampus. a IHC specific staining for the astrocyte marker (GFAP). EB recovered the devastating effects\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/The-estimation-of-hippocampal-neuron-and-glial-number-As-depicted-in-a-EB-diet.webp\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"9f2a2d5\" data-elementor-lightbox-title=\"The-estimation-of-hippocampal-neuron-and-glial-number-As-depicted-in-a-EB-diet\" data-elementor-lightbox-description=\"The estimation of hippocampal neuron and glial number. As depicted in a, EB diet recovered the number of cells in hippocampus. The effects of EB on the number of neurons (b), glial cells (c), and dark neurons (d) in METH treated rats. As shown in the graphs, although the number of neurons and glial cells significantly changed\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzY1OSwidXJsIjoiaHR0cHM6XC9cL3dlYi1mcmFua2Z1cnQuZGVcL1NhbmlcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA3XC9UaGUtZXN0aW1hdGlvbi1vZi1oaXBwb2NhbXBhbC1uZXVyb24tYW5kLWdsaWFsLW51bWJlci1Bcy1kZXBpY3RlZC1pbi1hLUVCLWRpZXQud2VicCIsInNsaWRlc2hvdyI6IjlmMmEyZDUifQ%3D%3D\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/The-estimation-of-hippocampal-neuron-and-glial-number-As-depicted-in-a-EB-diet.webp\" data-width=\"850\" data-height=\"574\" aria-label=\"The estimation of hippocampal neuron and glial number. As depicted in a, EB diet recovered the number of cells in hippocampus. The effects of EB on the number of neurons (b), glial cells (c), and dark neurons (d) in METH treated rats. As shown in the graphs, although the number of neurons and glial cells significantly changed\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t<a class=\"e-gallery-item elementor-gallery-item elementor-animated-content\" href=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/Y-maze-elevated-plus-maze-and-tail-suspension-test-TST-were-used-to-assess-working.webp\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-slideshow=\"9f2a2d5\" data-elementor-lightbox-title=\"Y-maze-elevated-plus-maze-and-tail-suspension-test-TST-were-used-to-assess-working\" data-elementor-lightbox-description=\"Y maze, elevated plus maze and tail suspension test (TST) were used to assess working memory, anxiety and depression respectively. a and b Despite a remarkable difference between the control and METH groups regarding spontaneous alteration index and total arm entries in Y-maze, these variables recovered by EB diet. Examination of anxiety-related behaviors with elevated plus maze apparatus showed that the percentage of time spent in the open arm (OAT), and the percentage of entries into the enclosed or open arms (OAE)\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6MzY2MCwidXJsIjoiaHR0cHM6XC9cL3dlYi1mcmFua2Z1cnQuZGVcL1NhbmlcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjVcLzA3XC9ZLW1hemUtZWxldmF0ZWQtcGx1cy1tYXplLWFuZC10YWlsLXN1c3BlbnNpb24tdGVzdC1UU1Qtd2VyZS11c2VkLXRvLWFzc2Vzcy13b3JraW5nLndlYnAiLCJzbGlkZXNob3ciOiI5ZjJhMmQ1In0%3D\">\n\t\t\t\t\t<div class=\"e-gallery-image elementor-gallery-item__image\" data-thumbnail=\"https:\/\/web-frankfurt.de\/Sani\/wp-content\/uploads\/2025\/07\/Y-maze-elevated-plus-maze-and-tail-suspension-test-TST-were-used-to-assess-working.webp\" data-width=\"850\" data-height=\"744\" aria-label=\"Y maze, elevated plus maze and tail suspension test (TST) were used to assess working memory, anxiety and depression respectively. a and b Despite a remarkable difference between the control and METH groups regarding spontaneous alteration index and total arm entries in Y-maze, these variables recovered by EB diet. Examination of anxiety-related behaviors with elevated plus maze apparatus showed that the percentage of time spent in the open arm (OAT), and the percentage of entries into the enclosed or open arms (OAE)\" role=\"img\" ><\/div>\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-gallery-item__overlay\"><\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c871d3f elementor-widget elementor-widget-text-editor\" data-id=\"c871d3f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"nova-legacy-e-text nova-legacy-e-text--size-l nova-legacy-e-text--family-sans-serif nova-legacy-e-text--spacing-xxs nova-legacy-e-text--color-grey-700 research-detail-figures-legal\" style=\"text-align: center;\">Figures &#8211; uploaded by\u00a0<a class=\"nova-legacy-e-link nova-legacy-e-link--color-inherit nova-legacy-e-link--theme-decorated\" href=\"https:\/\/www.researchgate.net\/profile\/Yaser-Khakpour?_tp=eyJjb250ZXh0Ijp7ImZpcnN0UGFnZSI6InB1YmxpY2F0aW9uIiwicGFnZSI6InB1YmxpY2F0aW9uIiwicHJldmlvdXNQYWdlIjoicHJvZmlsZSJ9fQ\">Yaser Khakpour<\/a><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Abstract and Figures June 2025 3 Biotech\u00a015(7) DOI: 10.1007\/s13205-025-04387-2 \u00a0The primary objective of this study was to investigate the effects of prolonged heroin exposure on adult male rats. Our findings demonstrate that this intervention induces deficits in memory, synaptic plasticity, emotional regulation, and motor function. These impairments appear to be associated with reduced levels of <\/p>\n","protected":false},"author":1,"featured_media":2815,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"class_list":["post-3667","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-scientific-articles"],"_links":{"self":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3667","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/comments?post=3667"}],"version-history":[{"count":4,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3667\/revisions"}],"predecessor-version":[{"id":3671,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/posts\/3667\/revisions\/3671"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/media\/2815"}],"wp:attachment":[{"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/media?parent=3667"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/categories?post=3667"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/web-frankfurt.de\/Sani\/wp-json\/wp\/v2\/tags?post=3667"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}